At the beginning, YARSI Foundation’s sole concern was the shortage of medical personnel in Indonesia, especially the low number of Muslims working in  health care. This was reflected in the fact that in 1967 none of the existing medical education institutions and hospitals was managed by an Islamic institution.

Concerned with this and realizing the potential of Muslims in Indonesia as a majority, on April 15, 1967, YARSI Foundation established YARSI Medical College, which later in 1969 was changed to YARSI Medical School in accordance with Law No. 22 of 1961.

The idea to expand the medical school to a university had been considered since 1979. With the experience of managing medical study programs which have proved to be successful, the foundation was optimistic that it would also be able to manage non-exact courses like Law, Economics and others.